DEFENSE ONE
Canadian firm says it could make 10 million doses per month — if its innovative production method wins FDA approval.
A Canadian company says that it has produced a COVID-19 vaccine just 20 days after receiving the coronavirus’s genetic sequence, using a unique technology that they soon hope to submit for FDA approval.
Medicago CEO Bruce Clark said his company could produce as many as 10 million doses a month. If regulatory hurdles can be cleared, he said in a Thursday interview, the vaccine could start to become available in November.
An Israeli research lab has also claimed to have created a vaccine. But Clark says his company’s technique, which has already been proven effective in producing vaccines for seasonal flu, is more reliable and easier to scale.
“There are a couple of others who are claiming that they have — well, we will call them vaccine[s]” for COVID-19, he said. “But they’re different technologies. Some are RNA– or DNA-based vaccines that have not yet been proven in any indication yet, let alone this one. Hopefully, they’ll be successful.”
How did Clark’s team create one so quickly,? They use plants, not chicken eggs, as a bioreactor for growing vaccine proteins.
Traditional vaccine production requires eggs, a lot of them. Vaccine manufacturers inject the virus into the eggs, where it propagates. But using eggs is expensive, takes a long time, and is far from perfect. Mutations can yield vaccines that don’t match up to the virus they aim to shut down, Clark said
“That’s the difference between us” and egg-based methods, he said, ”we go directly to producing the vaccine or the antibody without having to propagate the virus.”
Using plants and genetically engineered agrobacteria works faster than eggs also makes the vaccine much easier to produce at scale, which, in part, is why the U.S. military has invested in the company.
In 2010, the Defense Advanced Research Projects Agency, or DARPA, put together a $100 million program dubbed Blue Angel to look into new forms of vaccine discovery and production. A big chunk of that money went to Medicago to build a facility in North Carolina, where they showed that they could find a vaccine in just 20 days, then rapidly scale up production.
He said the only obstacles at this point are regulatory. The company’s technique isn’t yet FDA-approved and would need to go through clinical trials.
“Our basic plan is to be in human studies, phase one, by the July time frame; and then, it would depend, quite extensively, on the decisions the regulators make in terms of the hurdles they want us to have in the normal course of development,” he said.
Clark says that he understands that cutting corners in drug development invites risk. But, he says, “There’s a lot of room for negotiation with the regulators. I won’t put words in their mouths…I will say our intention, taking a very standard approach, is that by November we will have completed phase III,” in clinical trials — allowing the vaccine to be made widely available to the public.
Also on Thursday, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Disease at the National Institutes of Health, told the U.S. House Oversight and Reform Committee that human trials for a vaccine (he did not specify the manufacturer) would be possible “within a few weeks.” However, he said that a vaccine would not be available to the broader public for another 12 to 18 months.
@ adamdalgliesh:
This one is PENTAGON FUNDED. Do they need any more compensation from the public coffers?
It’s getting curiouser and curiouser.
I just hope they won’t force it on everybody.
Apparently several companies in several countries have developed workable vaccines for COVID-19. But it will take time to test them for saftety and effectiveness. It is possible that by the time the vaccine is usable, the epidemic may have ended. But id that happens will still be a good thing, although it may leave some companies with unused vaccines ain storage and the loss of their investment in developing the vaccines. If that happens, I hope that governments will compensate these public-spirited companies.